Biofunctionalized surfaces

The central topic of the lecture is the processes that take place when biomaterials are contacted by biological systems. Both the causes, the potential biological consequences and in particular the possibilities of influence through surface design on such interfacial processes are dealt with. The relevant foundations of cell communication and cell reaction to biochemical and physical properties are also considered against this background. Various methods of defined design of biomaterial surfaces are explained with particular attention (i) of biological backgrounds, (ii) methods for generating surface states, (iii) the surface properties to be sought and (iv) the cell biological, animal and clinical results. This includes:

• the production of defined morphologies by physical and chemical processes,
• physical/chemical modification of surface properties,
• inorganic coating systems as well as
• the field of BioSurface Engineering, i.e. the biomimetic replica of the native cell environment provided by the extracellular matrix (ECM).

In the latter, the possible uses of various components of the native ECM, (peptides, (structure) proteins, growth factors, glycosaminoglycans, nucleic acids, aptamers) for BioSurface engineering are presented and, depending on substrates and components, the advantages and disadvantages of immobilization strategies are comprehensively presented. This is discussed with examples from the current research of the Chair.

18.10.24               1 Contents//Interaction processes (VH)

25.10.24               2 Physico-chemical modifications (VH)

01.11.24               3 Electrochemical methods for surface functionalization I (UB)

08.11.24               4 Morphology (VH)

15.11.24               5 Immobilisation strategies (VH)

22.11.24               6 Growth factors and cytokines (VH)

29.11.24               7 Biofunctionality, cell communication and surfaces (SB)

06.12.24               8 BioSurface Engineering - Introduction (SB) Extracellular matrix II (SB)

13.12.24               9 Nanostructural effects (MHK)

20.12.24               10 Extracellular matrix I (SB)

10.01.25               11 Extracellular matrix II (SB)

17.01.25               12 Electrochemical methods for surface functionalization II (UB)

24.01.25               13 Animal models and analytical imaging methods (PSL)

31.01.25               Seminar

07.02.25               14 Q & A Exam Preparation

Lecturers: PD Dr. Vera Hintze (VH), Dr. Susanne Bierbaum (SB), Dr. Ute Bergmann (UB), Dr. Poh Soo Lee, Prof. Marie Hubalek Kalbacova (MHK)

Place: Seminar room Schweizer Straße 3, ground floor

Time: Fr 13:00 - 14:30 

The lecture is held in English and is aimed in particular at students of materials science, biotechnology and scientific studies in specialist studies and master's programmes.

Workload: 2 SWS lecture, 2 SWS exercise/seminar, self-study

Exam: Written exam (90 min) + Presentation (seminar) 

Important: The lecture will take place in presence at the seminar room, Schweizer Straße 3, ground floor! There will be the possibility to attend online via:

https://tu-dresden.zoom-x.de/j/62281926074?pwd=cPuM5sAgtxTkeLyRbx3YzmBFGp70xK.1

Meeting-ID: 622 8192 6074, Kenncode: A2=HzD%@

TU Dresden students are expected to attend in presence whenever possible!

The PDF versions of the lecture slides will be made available in the "Lecture" folder following each lecture in OPAL.

Please use the enrolment tool to register as a student for the lecture!